Key words: bronchoalveolar lavage fluid, chemokine CXCL11, interstitial lung diseases, systemic sclerosis

نویسندگان

  • Paolo Sfriso
  • Francesca Oliviero
  • Silvia Cardarelli
  • Angela Del Rosso
  • Marco Matucci-Cerinic
چکیده

1Department of Medicine, Rheumatology Unit, University of Padova, Padova, Italy: 2Department of Medicine, Clinical Immunology Branch, University of Padova, Padova, Italy; 3Department of Medical Diagnostic Sciences and Special Therapies, Radiology Section, University of Padova, Padova, Italy; 4Department of Biomedicine, Division of Rheumatology, University of Florence, Florence, Italy. Paolo Sfriso, MD, PhD Franco Cozzi, MD Francesca Oliviero, PhD Francesco Caso, MD, PhD Student Silvia Cardarelli, MD Monica Facco, PhD Claudio Fittà, MD Angela Del Rosso, MD, PhD Marco Matucci-Cerinic, MD, PhD Leonardo Punzi, MD, PhD Carlo Agostini, MD, PhD Please address correspondence and reprint requests to: Paolo Sfriso, MD, PhD Rheumatology Unit, Department of Medicine, University of Padova, via Giustiniani 2, 35128 Padova, Italy. E-mail: [email protected] Received on September 29, 2010; accepted in revised form on April 16, 2012. Clin Exp Rheumatol 2012; 30 (Suppl. 71): S71-S75. © Copyright CLINICAL AND EXPERIMENTAL RHEUMATOLOGY 2012.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

β-thymosins and interstitial lung disease: study of a scleroderma cohort with a one-year follow-up

BACKGROUND β-thymosins play roles in cytoskeleton rearrangement, angiogenesis, fibrosis and reparative process, thus suggesting a possible involvement in the pathogenesis of systemic sclerosis. The aim of the study was to investigate the presence of thymosins β4, β4 sulfoxide, and β10 in bronchoalveolar lavage fluid of scleroderma patients with interstitial lung disease and the relation of thes...

متن کامل

Bronchoalveoloar lavage fluid cytokines and chemokines as markers and predictors for the outcome of interstitial lung disease in systemic sclerosis patients

INTRODUCTION Interstitial lung disease (ILD) is a frequent manifestation of systemic sclerosis (SSc), and cytokines can contribute to the disease pathology. The aim of the current study was to identify specific changes in cytokine levels that may serve as disease markers and possible targets for therapy. METHODS Cytokines were measured with bioplex analysis in 38 bronchoalveolar fluids (BALFs...

متن کامل

Progression of interstitial lung disease upon overlapping of systemic sclerosis with polymyositis.

We describe a 73-year-old woman with systemic sclerosis (SSc)-polymyositis (PM) overlap syndrome, primarily SSc followed by PM. She had suffered from SSc and had interstitial pneumonia (IP), which was stable. Eight years after the initial diagnosis of SSc, proximal muscle weakness, myalgia, and dyspnea on effort developed. A chest computed tomography (CT) showed reticular shadows, and serum mar...

متن کامل

Evidence for protein oedema, neutrophil influx, and enhanced collagen production in lungs of patients with systemic sclerosis.

Bronchoalveolar lavage fluid from patients with systemic sclerosis was analysed for evidence of pulmonary vascular leakage, inflammatory cell influx, and enhanced type III collagen synthesis. Eighteen patients with systemic sclerosis and computed tomographic evidence of fibrosing alveolitis were compared with 16 patients with a normal scan. The albumin concentration in lavage fluid was higher i...

متن کامل

Activation of peripheral blood mononuclear cells in bronchoalveolar lavage fluid from patients with sarcoidosis: visualisation of single cell activation products.

BACKGROUND Interstitial lung diseases are characterised by the recruitment of mononuclear cells to disease sites where maturation occurs and activation products, including lysozyme (LZM), are released. Analysis of in vitro cell culture supernatants for activation products masks the functional heterogeneity of cell populations. It is therefore necessary to examine the secretion of activation pro...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2006